The Samuel Walker Houston Museum and Cultural Center was designed to preserve and perpetuate the legacy of one of Texas' greatest educators, Samuel Walker Houston. Originally opened in 1991 at 341 Old Madisonville Road on property leased from the Huntsville Independent School District. The facility closed in 2000 to make way for a new elementary school.

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In 2001, the Museum and Cultural Center reopened at its current location, 1604 10th Street. This site previously served as Huntsville's Negro High School. In 2013, the school district gift-deeded the property to the National Alumni Association of Samuel Walker Houston High School.

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The Samuel Walker Houston Museum and Cultural Center is pleased to offer tours to public and school groups. Topics covered include African American history, segregated education, and the African American civil rights movement.